KRISH LAB

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1. Roychowdhury, Sumangal,  Das,Bidisha et al.,"Cofactor-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation", Biophysical Journal (2023)

2. Das,Bidisha, Roychowdhury, Sumangal et al. "A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation" The EMBO Journal (2023)

3. Sanyal, Dwipanjan et.al, "An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)", International Journal of Biological Macromolecules (2022)

4.  Hazra,A, Sanyal,D, De,A, Chatterjee,S, Chattopadhyay, K, Samanta,A,  "Development and in vitro characterization of capecitabine loaded biopolymeric vehicle for the treatment of colon cancer"Journal of Applied Polymer Science (2022)

5. Mandal,Narattam, Chattopadhyay,Krishnananda ,Sannigrahi,Achinta, "Studying protein-folding dynamics using single-molecule fluorescence methods",(2022)

6. Sannigrahi,Achinta, Chattopadhyay, Krishnananda, "Pore formation by pore forming membrane proteins towards infections",Advances in Protein Chemistry and Structural Biology (2022)

7.  Mahapatra, Anindita et al., "Cholesterol in Synaptic Vesicle Membranes Regulates the Vesicle-Binding, Function, and Aggregation of α-Synuclein", The Journal of Physical Chemistry B, (2021)

8. Tiwari A, Pradhan S, Sannigrahi A ,Jha S, Chattopadhyay K, Biswas M, Saleem M, "In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation",BioRxiv (2021)

9.  Goswami S, Manna B,  Chattopadhyay K, Ghosh A, Datta S ,"Role of Conformational Change and Glucose Binding Sites in the Enhanced Glucose Tolerance of Agrobacterium tumefaciens 5A GH1 β-Glucosidase Mutants", The Journal of Physical Chemistry B (2021)

10.  Sen S, Dey A,  Sanyal D, Chattopadhyay  K,  Maulik U, "IMMUND: an Early Stage Diagnostic and Therapeutic Frame for Neurodegenerative Diseases and Multiple Sclerosis based on Immunological Markers" BioRxiv (2021)

11.  Chakraborty, Ritobrita, et al. "Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects." Communications Biology (2021)

12. Sannigrahi,Achinta, et al."The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model."Elife (2021)

13. Mahapatra, Anindita, et al. "Membrane Cholesterol Regulates the Binding of Alpha-Synuclein to Synaptic Vesicles, and Its Subsequent Functional and Pathogenic Behavior."Biophysical Journal(2021)

14. Krishnananda Chattopadhyay, "Probing the influence of mutations on FUS condensates, one molecule at a time." communication Biology (2021)

15. Bandyopadhyay, Arnab, et al., Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein." RSC Chemical Biology (2021).

16. Mahapatra, Anindita, et al. "Modulation of α-Synuclein Fibrillation by Ultra-small and Biocompatible Gold Nanoclusters." ACS Chemical Neuroscience (2020).

17. Mandal, Narattam, et al. "Correlation between CNS Tuberculosis and the COVID-19 Pandemic: The Neurological and Therapeutic Insights.” ACS Chemical Neuroscience (2020).

18. Sanyal, Dwipanjan, et al. "An exploration of the SARS-CoV-2 spike receptor binding domain (RBD), a complex palette of evolutionary and structural features." bioRxiv (2020).

19. ​Goswami, Avijit, et al. "MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages." EMBO molecular medicine 12.3 (2020): e11011.

20. ​Saha, Saumen, et al. "Interaction of KMP-11 and its mutants with ionic liquid choline dihydrogen phosphate: Multispectroscopic studies aided by docking and molecular dynamics simulations." Journal of Molecular Liquids 301 (2020): 112475.

21. ​Ghosh, Sumanta, et al. "A Novel Tool to Investigate the Early and Late Stages of α-Synuclein Aggregation." ACS Chemical Neuroscience 11.11 (2020): 1610-1619.

22. ​Halder, Animesh, et al. "Kinetoplastid Membrane Protein-11 Induces Pores in Anionic Phospholipid Membranes: Effect of Cholesterol." Langmuir 36.13 (2020): 3522-3530.

23. ​Kulsi, Goutam, et al. "A Novel Cyclic Mobile Transporter Can Induce Apoptosis by Facilitating Chloride Anion Transport into Cells." ACS omega 5.27 (2020): 16395-16405.

24. ​Sannigrahi, Achinta, Nayan De, and Krishnananda Chattopadhyay. "The bright and dark sides of protein conformational switches and the unifying forces of infections." Communications biology 3.1 (2020): 1-6.

25. ​Chakraborty, Ritobrita, and Krishnananda Chattopadhyay. "Protein Folding, Dynamics and Aggregation at Single-Molecule Resolution." Frontiers in Protein Structure, Function, and Dynamics. Springer, Singapore, 2020. 239-258.

26. Sannigrahi, Achinta, et al. "The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS Model." BioRxiv (2020).

27. ​Chattopadhyay, Krishnananda, Achinta Sannigrahi, and Arnab Bandyopadhyay. "Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein." bioRxiv (2020).

28. ​Sannigrahi, Achinta, et al. "Protein induced membrane phase transition facilitates leishmania infection." bioRxiv (2020).

29. ​Basak, Sujit, Sombuddha Sengupta, and Krishnananda Chattopadhyay. "Understanding biochemical processes in the presence of sub-diffusive behavior of biomolecules in solution and living cells." Biophysical reviews (2019): 1-22.

30. ​Chowdhury, S., Sen, S., Banerjee, A., Uversky, V.N., Maulik, U. and Chattopadhyay, K., 2019. Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra. Cellular and Molecular Life Sciences, pp.1-10.

31. ​Bandyopadhyay, Arnab, Indrani Bose, and Krishnananda Chattopadhyay. "Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae." PloS one 14.9 (2019).

32. ​Sannigrahi, Achinta, et al. "Development of a near infrared Au–Ag bimetallic nanocluster for ultrasensitive detection of toxic Pb 2+ ions in vitro and inside cells." Nanoscale Advances 1.9 (2019): 3660-3669.

33. Sannigrahi A, Nandi I, Chall S, Jawed JJ, Halder A, Majumdar S, Karmakar S, Chattopadhyay K. Conformational switch driven membrane pore formation by Mycobacterium secretory protein MPT63 induces macrophage cell death. ACS chemical biology. 2019 Jun 26.

34. ​Mahapatra, Anindita, et al. "An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro." Chemical Communications 55.74 (2019): 11052-11055.

35. ​Chaudhury, SS; Sannigrahi, A; Nandi, M; Mishra, VK; De, P; Chattopadhyay, K; Mishra, S; Sil, J; Mukhopadhyay, CD; A Novel PEGylated Block Copolymer in New Age Therapeutics for Alzheimer’s Disease. 2019, Molecular Neurobiology, 1-5

36. ​Chakraborty, R; Chattopadhyay, K; Cryo-Electron Microscopy Uncovers Key Residues within the Core of Alpha-Synuclein Fibrils. 2019, ACS chemical neuroscience, Feb 20

37. ​Ghosh, S; Chakraborty, B; Dey, S; Biswas, C; Chowdhury, R; Chattopadhyay, K; Sengupta, J; Electron microscopy reveals unique spore-like nano forms of Bacillus cereus. 2019, bioRxiv, Jan 1:228833.

38. ​Hazra, S; Bodhak, C; Chowdhury, S; Sanyal, D; Mandal, S; Chattopadhyay, K; Pramanik, A; A novel tryptamine-appended rhodamine-based chemosensor for selective detection of Hg 2+ present in aqueous medium and its biological applications. 2019, Analytical and bioanalytical chemistry, Jan 9:1-5

39. ​Ghosh, S; Mahapatra, A; Chattopadhyay, K; Modulation of Alpha-Synuclein Aggregation by Cytochrome c Binding and Hetero-di-Tyrosine Adduct Formation. 2019, ACS chemical neuroscience, Jan 8

40. Sannigrahi, A; Karmakar, S; Jawed, J; Majumdar, S; Chattopadhyay, K; An Interplay between KMP-11 Induced Phase Alteration of Macrophage Membrane and Immune Suppression Defines the Molecular Mechanism of Leishmaniasis. 2019, Biophysical Journal, Feb 15;116(3):373a

41. ​Chatterjee, S; Ghosh, S; Mishra, S; Das Saha, K; Banerji, B; Chattopadhyay, K; Efficient Detection of Early Events of Alpha Synuclein Aggregation using a Cysteine Specific Hybrid Scaffold. 2019, Biochemistry, Jan 29

42. ​Sannigrahi, A; Mullick, D; Sanyal, D; Sen, S; Maulik, U; Chattopadhyay, K; Effect of Ergosterol on the Binding of KMP-11 with Phospholipid Membranes: Implications in Leishmaniasis. 2019, ACS Omega, Mar 12; 4(3):5155-64

43. ​Mukherjee S, Hazra S, Chowdhury S, Sarkar S, Chattopadhyay K, Pramanik A. A novel pyrrole fused coumarin based highly sensitive and selective fluorescence chemosensor for detection of Cu2+ ions and applications towards live cell imaging. Journal of Photochemistry and Photobiology A: Chemistry. 2018 Sep 1; 364:635-44.

44. ​Sarkar-Banerjee S, Chowdhury S, Sanyal D, Mitra T, Roy SS, Chattopadhyay K. The Role of Intestinal Fatty Acid Binding Proteins in Protecting Cells from Fatty Acid Induced Impairment of Mitochondrial Dynamics and Apoptosis. Cellular Physiology and Biochemistry. 2018; 51(4):1658-78.

45. ​Chakraborty R, Sahoo S, Halder N, Rath H, Chattopadhyay K. Conformational-Switch Based Strategy Triggered by [18] π Heteroannulenes toward Reduction of Alpha Synuclein Oligomer Toxicity. ACS chemical neuroscience. 2018 Oct 19.

46. ​Sen S, Dey A, Chowdhury S, Maulik U, Chattopadhyay K. Understanding the evolutionary trend of intrinsically structural disorders in cancer relevant proteins as probed by Shannon entropy scoring and structure network analysis. BMC bioinformatics. 2019 Feb; 19(13):549.

47. ​Sannigrahi A, Chall S, Jawed JJ, Kundu A, Majumdar S, Chattopadhyay K. Nanoparticle Induced Conformational Switch Between α-Helix and β-Sheet Attenuates Immunogenic Response of MPT63. Langmuir. 2018 Jul 9; 34(30):8807-17.

48. ​S Ghosh, A Kundu, K Chattopadhyay. Small Molecules Attenuate the Interplay between Conformational Fluctuations, Early Oligomerization and Amyloidosis of Alpha Synuclein. Scientific reports, 2018, 8 (1), 5481.

49. ​S Sarkar-Banerjee, S Goyal, N Gao, J Mack, B Thompson, D Dunlap, K Chattopadhyay, L Finzi. Specifically bound lambda repressor dimers promote adjacent non-specific binding. PloS one, 2018 13 (4), e0194930.

50. ​B Saha, S Chowdhury, D Sanyal, K Chattopadhyay, G Suresh Kumar. Comparative Study of Toluidine Blue O and Methylene Blue Binding to Lysozyme and Their Inhibitory Effects on Protein Aggregation. ACS Omega, 2018, 3 (3), 2588-2601.

51. ​D Singharoy, S Chowdhury, SS Mati, S Ghosh, K Chattopadhyay, SC Bhattacharya. Photoinduced Electron Transfer Switching Mechanism of a Naphthalimide Derivative with its Solvatochromic Behaviour: An Experimental and Theoretical Study with In Cell Investigations. Chemistry–A European Journal, 2017, 23 (65), 16516-16524.

52. ​S Chall, SS Mati, I Das, A Kundu, G De, K Chattopadhyay. Understanding the Effect of Single Cysteine Mutations on Gold Nanoclusters as Studied by Spectroscopy and Density Functional Theory Modeling. Langmuir, 2017, 33 (43), 12120-12129.

53. S Chowdhury, A Banerjee, K Chattopadhyay. Metal ion co-factors sculpt the heterogeneity of conformational landscape in Superoxide Dismutase. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 46, S344-S344.

54. ​A Kundu, S Kundu, K Chattopadhyay. The presence of non‐native helical structure in the unfolding of a beta‐sheet protein MPT63. Protein Science, 2017, 26 (3), 536-549.

55. ​A Sannigrahi, P Maity, S Karmakar, K Chattopadhyay. Interaction of KMP-11 with phospholipid membranes and its implications in leishmaniasis: effects of single tryptophan mutations and cholesterol. The Journal of Physical Chemistry B, 2017, 121 (8), 1824-1834.

56. Sil P, Paul SS, Silvio ED, Travaglini-Allocatellib C, Chattopadhyay K. Polymer-fabricated synthesis of cerium oxide nanoparticles and applications as a green catalyst towards multicomponent transformation with size-dependent activity studies. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 18 (35), 24537-24548.

57. ​Sarkar-Banerjee, S.; Chowdhury, S.; Paul, S. S.; Dutta, D.; Ghosh, A.; Chattopadhyay, K., Non-native helical intermediate state may accumulate at low pH in the folding/aggregation landscape of the intestinal fatty acid binding protein. Biochemistry 2016.

58. ​Paul SS, Sil P, Chakraborty R, Haldar S, Chattopadhyay K. Molecular Crowding Affects the Conformational Fluctuations, Peroxidase Activity, and Folding Landscape of Yeast Cytochrome c. Biochemistry. 2016 Apr 26; 55(16):2332-43.

59. ​Mukherjee M, Ghosh R, Chattopadhyay K, Ghosh S. Stepwise Unfolding of a Multi-Tryptophan Protein MPT63 with Immunoglobulin like Fold: Detection of Zone-wise

60. Perturbation During Guanidine Hydrochloride Induced Unfolding Using Phosphorescence Spectroscopy. RSC Adv. 2016 (In Press)

61. ​Paul SS, Sil P, Haldar S, Mitra S, Chattopadhyay K. Subtle Change in the Charge Distribution of Surface Residues May Affect the Secondary Functions of Cytochrome c. J Biol Chem. 2015 Jun 5; 290(23):14476-90.

62. ​Kundu A, Ghosh S, Chattopadhyay K. The Effect of Small Molecules on Early and Late Events of Alpha Synuclein Aggregation in Solution and Inside Living Cells. Biophys. J. 2016 16 Feb; 110(3)

63. ​Mukherjee M, Ghosh R, Chattopadhyay K, Ghosh S. pH-induced structural change of a multi-tryptophan protein MPT63 with immunoglobulin-like fold: identification of perturbed tryptophan residue/residues. J Biomol Struct Dyn. 2015; 33(10):2145-60.

64. ​Joshi N, Basak S, Kundu S, De G, Mukhopadhyay A, Chattopadhyay K. Attenuation of the early events of α-synuclein aggregation: a fluorescence correlation spectroscopy and laser scanning microscopy study in the presence of surface-coated Fe3O4 nanoparticles. Langmuir. 2015 Feb 3; 31(4):1469-78.

65. ​Basak S, Prasad GV, Varkey J, Chattopadhyay K. Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46.

66. ​Haldar S, Sil P, Thangamuniyandi M, Chattopadhyay K. Conversion of amyloid fibrils of cytochrome c to mature nanorods through a honeycomb morphology. Langmuir. 2015 Apr 14; 31(14):4213-23.

67. Basak S, Chattopadhyay K. Studies of protein folding and dynamics using single molecule fluorescence spectroscopy. Phys Chem Chem Phys. 2014 Jun 21; 16(23):11139-49.

68. ​Paramanik B, Kundu A, Chattopadhyay K , Patra A. Study of binding interactions between MPT63 protein and Au nanocluster. RSC Adv. 2014 4, 35059-35066.

69. ​Sarkar S, Chattopadhyay K. Studies of early events of folding of a predominately β-sheet protein using fluorescence correlation spectroscopy and other biophysical methods. Biochemistry. 2014 Mar 11;53(9):1393-402.

70. ​Lahiri S, Banerjee S, Dutta T, Sengupta S, Dey S, Roy R, Sengupta D, Chattopadhyay K, Ghosh AK. Enzymatic and regulatory attributes of trehalose-6-phosphate phosphatase from Candida utilis and its role during thermal stress. J Cell Physiol. 2014 Sep; 229(9):1245-55.

71. ​Sharma S, Sarkar S, Paul SS, Roy S, Chattopadhyay K. A small molecule chemical chaperone optimizes its unfolded state contraction and denaturant like properties. Sci Rep. 2013 Dec 17; 3:3525.

72. ​Basak S, Chattopadhyay K. Fluorescence correlation spectroscopy study on the effects of the shape and size of a protein on its diffusion inside a crowded environment. Langmuir. 2013 Nov 26; 29(47):14709-17.

73. ​Ghosh R, Mukherjee M, Chattopadhyay K, Ghosh S. Unusual optical resolution of all four tryptophan residues in MPT63 protein by phosphorescence spectroscopy: assignment and significance. J Phys Chem B. 2012 Oct 18; 116(41):12489-500.

74. ​Lahiri S, Basu A, Sengupta S, Banerjee S, Dutta T, Soren D, Chattopadhyay K, Ghosh AK. Purification and characterization of a trehalase-invertase enzyme with dual activity from Candida utilis. Arch Biochem Biophys. 2012 Jun 15; 522(2):90-9.

75. ​Haldar S, Paul S, Joshi N, Dasgupta A, Chattopadhyay K. The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. PLoS One. 2012; 7(2):e31797.

76. ​Haldar S, Chattopadhyay K. Interconnection of salt-induced hydrophobic compaction and secondary structure formation depends on solution conditions: revisiting early events of protein folding at single molecule resolution. J Biol Chem. 2012 Mar 30; 287(14):11546-55.

77. ​Mukhopadhyay A, Joshi N, Chattopadhyay K, De G. A facile synthesis of PEG-coated magnetite (Fe3O4) nanoparticles and their prevention of the reduction of cytochrome c. ACS Appl Mater Interfaces. 2012 Jan; 4(1):142-9.

78. ​Haldar S, Chattopadhyay K. Effects of arginine and other solution additives on the self-association of different surfactants: an investigation at single-molecule resolution. Langmuir. 2011 May 17; 27(10):5842-9.

79. ​Mukhopadhyay A, Basak S, Das JK, Medda SK, Chattopadhyay K, De G. Ag-TiO2 nanoparticle codoped SiO2 films on ZrO2 barrier-coated glass substrates with antibacterial activity in ambient condition. ACS Appl Mater Interfaces. 2010 Sep; 2(9):2540-6.

80. ​Haldar S, Mitra S, Chattopadhyay K. Role of protein stabilizers on the conformation of the unfolded state of cytochrome c and its early folding kinetics: investigation at single molecular resolution. J Biol Chem. 2010 Aug 13; 285(33):25314-23.

81. Ghosh R, Sharma S, Chattopadhyay K. Effect of arginine on protein aggregation studied by fluorescence correlation spectroscopy and other biophysical methods. Biochemistry. 2009 Feb 10; 48(5):1135-43.

82. ​Chattopadhyay K, Frieden C. Steady-state and time-resolved fluorescence studies of the intestinal fatty acid binding protein. Proteins. 2006 May 1; 63(2):327-35.

83. ​Chattopadhyay K, Elson EL, Frieden C. The kinetics of conformational fluctuations in an unfolded protein measured by fluorescence methods. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2385-9.

84. ​Chattopadhyay K, Saffarian S, Elson EL, Frieden C. Measuring unfolding of proteins in the presence of denaturant using fluorescence correlation spectroscopy. Biophys J. 2005 Feb; 88(2):1413-22.

85. ​Chattopadhyay K, Mazumdar S. Stabilization of partially folded states of cytochrome c in aqueous surfactant: effects of ionic and hydrophobic interactions. Biochemistry. 2003 Dec 16; 42(49):14606-13.

86. ​Frieden C, Chattopadhyay K, Elson EL. What fluorescence correlation spectroscopy can tell us about unfolded proteins. Adv Protein Chem. 2002; 62:91-109.

87. ​Chattopadhyay K, Saffarian S, Elson EL, Frieden C. Measurement of microsecond dynamic motion in the intestinal fatty acid binding protein by using fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14171-6.

88. ​Chattopadhyay K, Das TK, Majumdar A, Mazumdar S. NMR studies on interaction of lauryl maltoside with cytochrome c oxidase: a model for surfactant interaction with the membrane protein. J Inorg Biochem. 2002 Jul 25; 91(1):116-24.

89. ​Chattopadhyay K, Zhong S, Yeh SR, Rousseau DL, Frieden C. The intestinal fatty acid binding protein: the role of turns in fast and slow folding processes.      Biochemistry. 2002 Mar 26; 41(12):4040-7.

90. ​K Chattopadhyay, S Mazumdar. Direct electrochemistry of heme proteins: effect of electrode surface modification by neutral surfactants.  Bioelectrochemistry. 2001 53(1): 17-24.

91. Chattopadhyay K, Mazumdar S. Structural and conformational stability of horseradish peroxidase: effect of temperature and pH. Biochemistry. 2000 39 (1), 263–270.

92. Chattopadhyay K, Mazumdar S. Direct electrochemical oxidation of horseradish peroxidase: cyclic voltammetric and spectroelectrochemical studies. New J. Chem. 1999 23: 137-139.